Abstract

Drug-induced liver injury (DILI) is an important but rare clinical adverse event and a potential complication of many drugs, which can range from liver enzyme elevations to severe liver failure, liver transplantation even death. The severity of DILI varies from person to person, depending on the type of drug and the state of patients. Most of the drugs commonly prescribed in clinical practice today can be classified as antibacterial, antifungals, and antivirals, which generally summarize the types of drugs that cause DILI. Based on the classification of these three drugs, we summarized the literatures of various databases including Pubmed, Embase, JAMA, Web of science, ranging from 1999 to 2020, and the keywords we searched contain drug-induced liver injury, hepatotoxicity, antibiotics, antimicrobial agents antibacterials, antifungals, antivirals, and cholestasis etc., and explained the incidence, main symptoms, duration and other related indicators of DILI with representative drugs of each type. In this review, we summarized and compared the liver injury caused by different anti-infective drugs, which can guide clinicians in the treatment of patients with drug-induced liver injury complicated with infection.