https://ijcmcr.com A peer-reviewed, open access journal publishing clinical case reports, case series and clinical images across medicine and surgery. CC BY 4.0. en Sun, 23 Aug 26 21:25:42 +0000 International Journal of Clinical & Medical Case Reports https://ijcmcr.com/maternal-cardiopulmonary-failure-in-rheumatic-heart-disease-gaps-in-cardio-obstetric-care-in-resource-limited-settings https://ijcmcr.com/maternal-cardiopulmonary-failure-in-rheumatic-heart-disease-gaps-in-cardio-obstetric-care-in-resource-limited-settings Mon, 27 Apr 26 00:00:00 +0000 Rheumatic heart disease (RHD) continues to be a major cause of maternal death in low- and middle-income countries (LMICs), where access to preconception counseling and coordinated cardio-obstetric care is often limited. We describe the case of a 35-year-old woman with a known history of RHD who stopped cardiac follow-up after becoming pregnant. She presented in her second trimester with worsening breathlessness and was found to have advanced valvular disease and pulmonary hypertension. Despite m... Temiloluwa Dorcas Owolabi Huldah Nyansarora Salim International Journal of Clinical & Medical Case Reports https://ijcmcr.com/acute-myocardial-infarction-with-initially-normal-ecg-the-importance-of-serial-evaluation https://ijcmcr.com/acute-myocardial-infarction-with-initially-normal-ecg-the-importance-of-serial-evaluation Mon, 27 Apr 26 00:00:00 +0000 Background: Acute myocardial infarction (AMI) may present with non-specific symptoms and initially normal electrocardiographic findings, leading to potential misdiagnosis and delayed treatment. Case Presentation: A 45-year-old previously healthy male presented to the emergency department with central chest discomfort described as burning, initially attributed to gastroesophageal reflux disease (GERD). Initial vital signs were stable, and the first electrocardiogram (ECG) showed no significant ab... Osama Issa International Journal of Clinical & Medical Case Reports https://ijcmcr.com/post-viral-gastroparesis-secondary-to-glp-1-receptor-agonist-use https://ijcmcr.com/post-viral-gastroparesis-secondary-to-glp-1-receptor-agonist-use Thu, 16 Apr 26 00:00:00 +0000 Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of injectables used in the management of type 2 diabetes mellitus (T2DM) and more recently obesity. This case report highlights an incidence of post viral gastroparesis of 12 days secondary to long term GLP-1 receptor agonist use in a 28-year-old male with nil other medical history besides obesity. Post viral gastroparesis due to GLP-1 receptor agonist is a novel adverse effect that has not been formally documented in the current lite... Samrudh Shaju International Journal of Clinical & Medical Case Reports https://ijcmcr.com/differential-diagnosis-of-kikuchi-fujimoto-disease-rare-presentation-of-histiocytic-necrotizing-lymphadenitis https://ijcmcr.com/differential-diagnosis-of-kikuchi-fujimoto-disease-rare-presentation-of-histiocytic-necrotizing-lymphadenitis Sat, 04 Apr 26 00:00:00 +0000 Kikuchi-Fujimoto Disease (KFD), also known as Histiocytic necrotizing lymphadenitis, is a rare case of cervical lymphadenopathy. Patients usually present with localized lymphadenopathy, fever and fatigue. [2] Because of the poorly understood etiology, it can be mistaken for an infectious disease or even malignancy [2]. Here we discuss a case of KFD that initially presented with left sided cervical lymphadenopathy. Due to its characteristic overlap with other disorders like Tuberculuos lymphadeni... Nali Hada Ujama Hussain Bibhant Shah Nagama Husain International Journal of Clinical & Medical Case Reports https://ijcmcr.com/comprehensive-management-of-major-wound-over-the-right-index-following-a-crush-injury-in-19-year-old-male-patient https://ijcmcr.com/comprehensive-management-of-major-wound-over-the-right-index-following-a-crush-injury-in-19-year-old-male-patient Sat, 14 Feb 26 00:00:00 +0000 Comprehensive Management Of Major Wound Over The Right Index Following A Crush Injury In 19-Year-Old Male Patient Deepali Ghungrud Pranita Rai Swapna Morey International Journal of Clinical & Medical Case Reports https://ijcmcr.com/an-unusual-clinical-presentation-of-a-patient-with-left-leg-ulcer-challenges-in-management https://ijcmcr.com/an-unusual-clinical-presentation-of-a-patient-with-left-leg-ulcer-challenges-in-management Sat, 14 Feb 26 00:00:00 +0000 An Unusual Clinical Presentation Of A Patient With Left Leg Ulcer Challenges In Management Deepali Ghungrud Mahi Chatap Swapna Morey International Journal of Clinical & Medical Case Reports https://ijcmcr.com/reliability-investigation-of-radiation-therapists-assessment-for-radiation-induced-skin-toxicity https://ijcmcr.com/reliability-investigation-of-radiation-therapists-assessment-for-radiation-induced-skin-toxicity Sat, 14 Feb 26 00:00:00 +0000 Purpose: Enhancing the quality of radiotherapy for skin cancer requires systematic evaluation of radiation-induced skin toxicity, particularly acute toxicity, which affects ~90% of patients receiving ionizing radiation. This study assessed the reliability of a newly developed visual grading tool, the Clinician Erythema Assessment-Radiation Therapy (CEA-RT), designed to help radiation clinicians evaluate early radiation dermatitis. Methods and Materials: The CEA-RT tool utilizes a 5-point scale.... Lilian Doerwald-Munoz Joseph Hayward M.H. Aref Qiyin Fang Ramy Abdlaty International Journal of Clinical & Medical Case Reports https://ijcmcr.com/pseudo-brain-death-after-neurotoxic-snakebite-a-case-report https://ijcmcr.com/pseudo-brain-death-after-neurotoxic-snakebite-a-case-report Fri, 16 Jan 26 00:00:00 +0000 Snakebite envenomation remains a major public health problem in tropical regions [1,4] and can rarely present with severe neuroparalysis mimicking brain death. Neurotoxic bites, particularly from elapid snakes, contain α- and β-neurotoxins that disrupt neuromuscular transmission, leading to descending paralysis, bulbar involvement, and respiratory failure. In severe cases, paralysis may cause absent brainstem reflexes, a phenomenon referred to as pseudo–brain death [7-9]. Such presentations are... Priyanka Thakur International Journal of Clinical & Medical Case Reports https://ijcmcr.com/case-report-on-embryonal-rhabdomyosarcoma-in-a-7-year-old-male-child https://ijcmcr.com/case-report-on-embryonal-rhabdomyosarcoma-in-a-7-year-old-male-child Fri, 16 Jan 26 00:00:00 +0000 Rhabdomyosarcoma is a rare and aggressive soft-tissue tumor that starts in skeletal muscle cells. It mainly affects children. Early diagnosis and treatment improve survival rates. We report the case of a 7-year-old boy with embryonal rhabdomyosarcoma who showed a progressively enlarging chest wall swelling and was treated with chemotherapy, followed by surgery. Imaging studies, biopsy, and a PET scan confirmed malignant cells. The child responded well to chemotherapy and was referred for ongoing... Abhir Labhane Asmita Dodke Priyanka Meshram Roshni Warghane Khushbu Meshram International Journal of Clinical & Medical Case Reports https://ijcmcr.com/splenic-infarct-in-an-immunocompetent-patient-with-cmv-infection-a-case-report-and-a-review-of-the-literature https://ijcmcr.com/splenic-infarct-in-an-immunocompetent-patient-with-cmv-infection-a-case-report-and-a-review-of-the-literature Fri, 16 Jan 26 00:00:00 +0000 Infection with Cytomegalovirus (CMV) is very common among the adult population, with a prevalence of 50-90%, varying according with age, country and socioeconomic status. Although its presentation in immunocompetent adults is usually mild and a self-limited flu-like syndrome is often the rule, the immunocompromised patients are quite vulnerable, as this herpes virus can significantly increase the morbidity and mortality among them. CMV infection has been linked with thromboembolic events not onl... Dimitra Tsogka Theofilos Avdis Despina Avramidou Dimitris Tsavaris Melanie Deutsch Georgios Kontos Hariklia Kranidioti International Journal of Clinical & Medical Case Reports https://ijcmcr.com/balancing-thrombosis-prevention-and-bleeding-risks-intricate-management-of-a-patient-with-advanced-cardiac-disease-and-g https://ijcmcr.com/balancing-thrombosis-prevention-and-bleeding-risks-intricate-management-of-a-patient-with-advanced-cardiac-disease-and-g Sat, 03 Jan 26 00:00:00 +0000 We report a challenging case of a 68-year-old man with advanced gastric adenocarcinoma and severe dilated cardiomyopathy (DCM; EF 25%), highlighting perioperative management complexities to balance thrombosis prevention and bleeding risk. Preoperative evaluation revealed significant systolic dysfunction and coronary artery disease. A multidisciplinary team planned an open Roux-en-Y total gastrectomy to optimize oncological outcomes while minimizing anesthesia-related cardiac risks. Key intervent... Gadisa Musa Wako Melat Adugna Asnake Eman Musa Wako Feven Birara Tesfaye International Journal of Clinical & Medical Case Reports https://ijcmcr.com/a-rare-presentation-of-ludwigs-angina-following-dental-extraction-a-case-report https://ijcmcr.com/a-rare-presentation-of-ludwigs-angina-following-dental-extraction-a-case-report Sat, 03 Jan 26 00:00:00 +0000 Ludwig’s Angina is a rare, rapidly advancing cellulitis of the submandibular, sublingual, and submental spaces, usually caused by odontogenic infections. Here, we report the case of a 48-year-old diabetic male who developed Ludwig’s Angina after molar removal. Although he underwent incision and drainage at an outpatient centre initially, his condition deteriorated, resulting in respiratory distress and stridor. CT scan showed multiloculated collections extending to the parapharyngeal and pre-epi... Padma Priya RM International Journal of Clinical & Medical Case Reports https://ijcmcr.com/priapism-as-presenting-manifestation-of-pediatric-chronic-mueloid-leukemia-in-a-non-pubescent-case-of-humano-murian https://ijcmcr.com/priapism-as-presenting-manifestation-of-pediatric-chronic-mueloid-leukemia-in-a-non-pubescent-case-of-humano-murian Sat, 03 Jan 26 00:00:00 +0000 An 8-year-old boy with a 3-day history of tense, rigid, and painful penis presented to the urology department. There was no history of trauma or medication use. The physical examination showed splenomegaly and laboratory investigations revealed leukocytosis with left shift, suggesting the possibility of a myeloproliferative neoplasm. The patient underwent corporal-glandular shunt surgery for priapism, successfully resolving the condition. However, the further evaluation indicated pediatric chron... Sérend Hipe International Journal of Clinical & Medical Case Reports https://ijcmcr.com/the-w-to-v-technique-an-effective-method-for-nasal-valve-repair https://ijcmcr.com/the-w-to-v-technique-an-effective-method-for-nasal-valve-repair Fri, 19 Dec 25 00:00:00 +0000 Introduction: The internal nasal valve is the narrowest segment of the nasal airway, making nasal valve stenosis (NVS) a major contributor to nasal obstruction. Prior rhinoplasty is a frequent cause of NVS. Although multiple surgical techniques have been described, the quality of supporting evidence remains low, resulting in continued debate about the optimal management strategy. Objective: To describe a novel, “W-to-V” technique for treating NVS and to evaluate postoperative improvement in nasa... Amani Daoud Amiel Dror Shiri Geva Insaf Saffoury Tali Jane-Ohayon Eyal Sela International Journal of Clinical & Medical Case Reports https://ijcmcr.com/current-challenges-of-antibiotic-resistance-in-the-middle-east-a-concise-review https://ijcmcr.com/current-challenges-of-antibiotic-resistance-in-the-middle-east-a-concise-review Fri, 19 Dec 25 00:00:00 +0000 Antimicrobial resistance (AMR) represents one of the most pressing global health challenges, with the Middle East emerging as a region of particular concern due to escalating resistance rates across multiple pathogen classes. This mini review synthesizes current evidence on the epidemiology, contributing factors, and intervention strategies related to antibiotic resistance in Middle Eastern countries. A comprehensive analysis of literature published between 2020 and 2025 reveals alarmingly high... Andrey Akinin International Journal of Clinical & Medical Case Reports https://ijcmcr.com/cervicofacial-cellulitis-in-hiv-positive-patients-two-case-reports https://ijcmcr.com/cervicofacial-cellulitis-in-hiv-positive-patients-two-case-reports Tue, 02 Dec 25 00:00:00 +0000 Introduction: Cervicofacial cellulitis is a life-threatening infectious emergency, most often of odontogenic origin. In immunocompromised patients, especially those living with HIV, clinical presentations may be atypical and disease progression more severe. Case presentation: We report two HIV-positive patients with severe cervicofacial cellulitis. Both presented with extensive involvement of deep cervical spaces. One case was complicated by mediastinitis and septic shock. Both patients were man... Imen Zoghlami Nadia Romdhane Wejdan Mohamed Trabelsi Dorra Chiboub Safa Nefzaoui Emna Rejeb Ines Hariga Chiraz Mbarek International Journal of Clinical & Medical Case Reports https://ijcmcr.com/when-standard-options-are-unavailable-managing-hypertensive-urgency-in-a-rural-primary-care-setting-a-case-of-clinical-a https://ijcmcr.com/when-standard-options-are-unavailable-managing-hypertensive-urgency-in-a-rural-primary-care-setting-a-case-of-clinical-a Tue, 02 Dec 25 00:00:00 +0000 Hypertensive urgency is characterized by a marked elevation in blood pressure without acute target organ damage. In rural primary care settings, management can be challenging due to limited drug availability, diagnostic tools, and specialist access. A 48-year-old male presented to a rural clinic with palpitations but no chest pain, dyspnea, or neurological symptoms. His blood pressure was 230/120 mmHg with a heart rate of 104 bpm. Physical examination was unremarkable, and ECG showed ST-segment... Audrey Fabianisa Mirza Charys Rifani Masharto Petrina Romana Ginting International Journal of Clinical & Medical Case Reports https://ijcmcr.com/pulmonary-hydatid-cyst-in-an-algerian-cohort-diagnostic-features-and-5-year-follow-up https://ijcmcr.com/pulmonary-hydatid-cyst-in-an-algerian-cohort-diagnostic-features-and-5-year-follow-up Sat, 11 Oct 25 00:00:00 +0000 Pulmonary Hydatid Cyst in an Algerian Cohort: Diagnostic Features and 5-Year Follow-Up International Journal of Clinical & Medical Case Reports https://ijcmcr.com/sex-cord-stromal-tumour-not-elsewhere-classified-a-case-report-and-review-of-the-literature https://ijcmcr.com/sex-cord-stromal-tumour-not-elsewhere-classified-a-case-report-and-review-of-the-literature Thu, 31 Jul 25 00:00:00 +0000 This case report represents one of the fews present in the scientific literature dealing with sex cord-stromal tumours. They are rare in the paediatric population and their incidence represents less than 5% of the testicular tumours in children and adolescents, and as a consequence little is known in the scientific community about them and how should be treated. In the following case report a five-month-old caucasian child in completely well-being was diagnosed with sex cord stromal tumour not e... Eugenia Piro Fabiola Colombini Veronica Zocca Lucia Vallieri Marta Brugnoni Dadiele Perilli Laura Caterina Abati Elena De Lorenzi International Journal of Clinical & Medical Case Reports https://ijcmcr.com/sensenual-deafness-and-facial-palsy-a-rare-presentation-of-granulomatosis-with-polyangiitis-in-a-saudi-patient-case-repo https://ijcmcr.com/sensenual-deafness-and-facial-palsy-a-rare-presentation-of-granulomatosis-with-polyangiitis-in-a-saudi-patient-case-repo Wed, 30 Jul 25 00:00:00 +0000 Granulomatosis with polyangiitis (GPA) is a rare autoimmune vasculitis typically affecting the respiratory tract and kidneys. This case report describes a 33-year-old Saudi female presenting with persistent otitis media, progressive hearing loss, and facial nerve paralysis unresponsive to conventional treatment. She later developed systemic symptoms, including oral ulcers, gastrointestinal bleeding, and a cecal mass. Histopathological analysis of the middle ear and cecal tissue confirmed GPA, de... Mariam Alamro Sultan Mogren Almogairen Alhassan Jaban Algazlan Fatima S. Alangari International Journal of Clinical & Medical Case Reports https://ijcmcr.com/now-is-the-time-to-put-ilc-in-the-front https://ijcmcr.com/now-is-the-time-to-put-ilc-in-the-front Thu, 12 Jun 25 00:00:00 +0000 Background: Invasive lobular Carcinoma (ILC) is distinguished from Invasive Ductal Carcinoma (IDC) via negative E-cadherin staining. Accumulating data reveal different biological and clinical behavior of ILC in both early and metastatic breast cancer. Thus, IDC usually present as a solid mass while ILC tend to present as non-mass enhancement. Clinically, ILC tends to spread to the ovaries, peritoneum and meninges and is more resistant to chemotherapy. Current international guidelines do not cons... Adi Faragi Rasco International Journal of Clinical & Medical Case Reports https://ijcmcr.com/giant-abdominal-cerebrospinal-fluid-pseudo-cyst-a-case-report https://ijcmcr.com/giant-abdominal-cerebrospinal-fluid-pseudo-cyst-a-case-report Mon, 09 Jun 25 00:00:00 +0000 The cerebrospinal fluid pseudocyst is an uncommon complication of the ventriculoperitoneal shunt used to treat hydrocephalus. It manifests as the accumulation of fluid around the distal end of the catheter, surrounded by a fibrous wall lacking epithelium. Its exact origin remains uncertain. We present here a case of a large peritoneal pseudocyst, filling the abdominal cavity and exerting pressure on adjacent structures. Management involved external drainage followed by the implantation of a new... Amal Mojahid Nadia El Mahi Hamid Ziani Nasri Siham Imane Kamaoui Imane Skiker International Journal of Clinical & Medical Case Reports https://ijcmcr.com/ventriculitis-and-pneumocephalus-secondary-to-tracheoesophageal-and-spinal-esophageal-fistulas-in-esophageal-carcinoma-a https://ijcmcr.com/ventriculitis-and-pneumocephalus-secondary-to-tracheoesophageal-and-spinal-esophageal-fistulas-in-esophageal-carcinoma-a Mon, 09 Jun 25 00:00:00 +0000 Background: Tracheoesophageal (TEFs) and spinal-esophageal fistulas (SEFs) are rare complications of advanced esophageal carcinoma. While TEFs are relatively well-documented, SEFs remain exceedingly uncommon and present unique neurosurgical challenges, especially when complicated by central nervous system (CNS) infections or pneumocephalus. Case Description: We report the case of a 51-year-old man with recurrent esophageal squamous cell carcinoma who developed both TEF and SEF following stent pl... Gulce Gel International Journal of Clinical & Medical Case Reports https://ijcmcr.com/atopic-dermatitis-and-inflammation-on-the-depressions-of-the-thoracic-vertebrate-t1-t4-a-proposal-based-on-electroacupun https://ijcmcr.com/atopic-dermatitis-and-inflammation-on-the-depressions-of-the-thoracic-vertebrate-t1-t4-a-proposal-based-on-electroacupun Tue, 18 Feb 25 00:00:00 +0000 Background: Atopic dermatitis (AD) is a chronic, relapsing inflammatory disease that causes skin redness and pruritus and challenging to cure. However, our understanding of its pathology remains limited. Acupuncture and Chinese herbs have historically been used to treat AD, yet their mechanisms of action are not fully understood. Objective: Elucidate the mechanisms underlying Willow's AD quadruple combo therapy and explore the possible link between inflammation in the depressions below the 1st t... Willow JH Liu International Journal of Clinical & Medical Case Reports https://ijcmcr.com/future-challenges-for-vaccinology https://ijcmcr.com/future-challenges-for-vaccinology Mon, 30 Dec 24 00:00:00 +0000 Vaccination is one of the most value-powerful healthcare interventions, saving more lives than other clinical remedies or remedies. a hit immunization packages have made many not unusual illnesses of the early 20th century, which include smallpox and polio, almost remarkable these days. Moreover, vaccination programs have substantially boosted food manufacturing by lowering the superiority of infectious sicknesses in cattle, which include rooster, cattle, and dairy animals. But, despite those su... Rehan Haider Asghar Mehdi Geetha Kumari Das Zameer Ahmed Sambreen Zameer International Journal of Clinical & Medical Case Reports https://ijcmcr.com/rare-case-report-clinical-and-immunological-insights-into-zap-70-deficiency https://ijcmcr.com/rare-case-report-clinical-and-immunological-insights-into-zap-70-deficiency Fri, 20 Dec 24 00:00:00 +0000 ZAP-70 deficiency is a rare primary immunodeficiency disorder characterized by a severe defect in T-cell receptor signaling, leading to impaired immune function. Early diagnosis and intervention play a crucial role in preventing life-threatening infections and improving patient outcomes. We presented a case involving a novel mutation in the ZAP 70 gene, presented with Burkholderia cepacia, an uncommon pathogen. Immunological assessment guided genetic testing, which confirmed the diagnosis throug... Maya Gupta Omkar Khandkar Shweta Shinde Umair Bargir Neha Bhongale Amrita Mehta Poonam Wade Manisha Madkaikar International Journal of Clinical & Medical Case Reports https://ijcmcr.com/the-global-burden-of-diabetes https://ijcmcr.com/the-global-burden-of-diabetes Sat, 16 Nov 24 00:00:00 +0000 Diabetes has emerged as a major health problem worldwide, with serious health-related and socioeconomic impacts on individuals and populations. Furthermore, the pandemic growth of diabetes is being spurred on by transitioning demographics (e.g. population aging), socioeconomic, migratory, nutritional, and lifestyle patterns, and an affiliated proliferation of overweight and obese adults and children. The International Diabetes Federation estimated 285 million people with diabetes worldwide in 20... Rehan Haider Geetha Kumari Das Zameer Ahmed Sambreen Zameer International Journal of Clinical & Medical Case Reports https://ijcmcr.com/infections-in-gynecological-practice-implications-for-womens-health https://ijcmcr.com/infections-in-gynecological-practice-implications-for-womens-health Tue, 12 Nov 24 00:00:00 +0000 Infections stay a substantial global fitness venture, contributing to full-size morbidity and mortality across diverse populations. They may be a result of numerous pathogens, such as microorganisms, viruses, fungi, and parasites. Notwithstanding advances in diagnostic tools, healing interventions, and vaccines, the rise of antimicrobial resistance (AMR) poses an escalating chance to public fitness. The evolution of multidrug-resistant (MDR) organisms has outpaced the improvement of novel antibi... Rehan Haider International Journal of Clinical & Medical Case Reports https://ijcmcr.com/sickle-cell-anemia-in-pediatrics-african https://ijcmcr.com/sickle-cell-anemia-in-pediatrics-african Wed, 30 Oct 24 00:00:00 +0000 Sickle cell disease is a genetic blood disorder affecting Red-blood cells. Is an umbrella term for a group of life-long debilitating autosomal recessive disorders that are caused by a single-point mutation (Glu→Va) that results in polymerization of hemoglobin (Hb) and reversible sickle-shape deformation of erythrocytes. The most common form of SCD is caused by homozygosity for the -globin S gene mutation (SS disease). The United Nations has recognized SCD as a global public health concern, and t... Ali Yousif Mohammed Salih Ekram Adam Edris Fatima Alzhraa Atif Alhadi Layla Ahmed Altayeb Mawa Mahjoob Alsied Rawan Almegdad Khalifa Yageen Abd Almonem Awad Amjad Hussien Abd Alrahman International Journal of Clinical & Medical Case Reports https://ijcmcr.com/case-report-of-microbial-contamination-on-n95-masks-used-by-health-care-workers https://ijcmcr.com/case-report-of-microbial-contamination-on-n95-masks-used-by-health-care-workers Fri, 18 Oct 24 00:00:00 +0000 The prevalence of pandemics, such as COVID-19 transmitted through the respiratory system, is a serious global public health concern. Microbial contamination of face masks used by healthcare workers may vary depending on the degree of exposure to bioaerosol in various healthcare environments; however, data on this topic are limited. Therefore, in this study, we analyzed the microbial contamination of N95 masks used in hospital offices, wards, and outpatient settings. Total indoor airborne bacteri... Hyekyung Seo International Journal of Clinical & Medical Case Reports https://ijcmcr.com/the-glb-anc-bone-metastasis-and-pd-l1-are-potential-predictive-markers-for-the-prognosis-of-advanced-or-metastatic-nsclc https://ijcmcr.com/the-glb-anc-bone-metastasis-and-pd-l1-are-potential-predictive-markers-for-the-prognosis-of-advanced-or-metastatic-nsclc Mon, 05 Aug 24 00:00:00 +0000 Immune checkpoint inhibitors (ICIs) hold a great promise in treatment of non-small cell lung cancer (NSCLC), while only a portion of patients benefited from the treatment, and others could not achieve optimal therapeutic effects from initial immunotherapy, even for those patients with PD-L1 tested positive. However, the clinical markers for the selection of patients who will benefit from ICIs treatment before hand are largely unknown. In this study, a retrospective analysis was conducted on base... Maike Zheng Mingming Hu Yanxia Liu Xiaomi Li Guirong Wang Tongmei Zhang Yan Zhao International Journal of Clinical & Medical Case Reports https://ijcmcr.com/an-overview-of-the-production-extraction-and-applications-of-egg-yolk-antibody-igy https://ijcmcr.com/an-overview-of-the-production-extraction-and-applications-of-egg-yolk-antibody-igy Mon, 13 May 24 00:00:00 +0000 Hens produce a class of antibodies called IgY whose natural role is to protect the chicken and the growing chick inside the egg. The overall structure of the IgY molecule is similar to mammalian immunoglobulin. Egg yolk antibody (IgY) can be a suitable alternative to IgG due to its unique characteristics, cost-effectiveness, and compliance with the ethical principles of working with animals. The process of immunization of chickens, production of specific antibodies against antigens, and purifica... Hadis Gandomkar Mir Mohammad Reza Hosseini Ahmad Zavaran Hosseini International Journal of Clinical & Medical Case Reports https://ijcmcr.com/appearance-of-round-atelectasis-on-radiological-images https://ijcmcr.com/appearance-of-round-atelectasis-on-radiological-images Wed, 10 Apr 24 00:00:00 +0000 Appearance Of Round Atelectasis On Radiological Images M Rhaouti F Lamouime I Arramach M Lakranbi Y Ouadnouni M Smahi International Journal of Clinical & Medical Case Reports https://ijcmcr.com/hepatic-portal-venous-gas-associated-with-ischemic-colitis-a-case-report https://ijcmcr.com/hepatic-portal-venous-gas-associated-with-ischemic-colitis-a-case-report Wed, 10 Apr 24 00:00:00 +0000 Background: Cases of Hepatic portal venous gas (HPVG) have been associated with high mortality rates and frequently require emergency exploratory laparotomy. However, the widespread utilization of computed tomography (CT) scans has revealed that HPVG is often connected to benign conditions, as demonstrated by numerous studies. Given the intricate nature of the underlying causes of HPVG, there remains a lack of consensus regarding the necessity of emergency surgical exploration for patients with... Qianqian Zhou Lian Lin Junlong Gao Hong Zhang International Journal of Clinical & Medical Case Reports https://ijcmcr.com/investigation-of-mirna-mirna-network-and-critical-targets-in-the-progression-of-alzheimers-disease https://ijcmcr.com/investigation-of-mirna-mirna-network-and-critical-targets-in-the-progression-of-alzheimers-disease Thu, 29 Feb 24 00:00:00 +0000 Alzheimer’s disease (AD) is a neurologic ailment that causes the brain to atrophy and brain cells to die over time. AD is the most prevalent form of dementia, which is a gradual decrease in cognitive, behavioral, and social abilities that impairs a person’s capacity to operate independently. In this study, bioinformatics analysis was conducted to look into possible miRNA-mRNA couples implicated in the etiology of AD to find DEmiRNAs and genes unique to Alzheimer’s disease. Two suitable datasets... Pedram Asadi Sarabi Ahmad Bereimipour Sara Taleahmad International Journal of Clinical & Medical Case Reports https://ijcmcr.com/successful-pregnancy-in-a-patient-with-iga-nephropathy-treated-with-telitacicept-a-case-report-and-literature-review https://ijcmcr.com/successful-pregnancy-in-a-patient-with-iga-nephropathy-treated-with-telitacicept-a-case-report-and-literature-review Mon, 12 Feb 24 00:00:00 +0000 IgA nephropathy (IgAN) is the most common cause of primary glomerulonephritis, with complex pathogenic mechanisms involving abnormal B cell activation. As a novel biologic agent, Telitacicept inhibits both B-lymphocyte stimulator and a proliferation-inducing ligand, can reduce B cell-mediated autoimmune responses, suppressing the production of galactose-deficient IgA1 and thereby inducing disease remission. Women with IgAN are at a higher risk of adverse pregnancy outcomes such as preeclampsia a... Xinru Du Geng Tian Xinyu Gao Xuehong Lu International Journal of Clinical & Medical Case Reports https://ijcmcr.com/mycobacterium-chelonae-line-sepsis-in-a-4-year-old-male-with-acute-myeloid-leukaemia-aml https://ijcmcr.com/mycobacterium-chelonae-line-sepsis-in-a-4-year-old-male-with-acute-myeloid-leukaemia-aml Fri, 22 Dec 23 00:00:00 +0000 Background: Mycobacterium chelonae (MC) was isolated from an immunosuppressed four-year-old with Acute Myeloid Leukaemia. This was initially dismissed as gram positive bacilli diptheroid based on gram staining. Several more blood culture bottles flagged up positive in quick succession. A review of the gram stain with additional ZN staining revealed acid-fast bacilli and finally identified as Mycobacterium chelonae. Case presentation: A 4-year-old (now 5) male with acute myeloid leukaemia present... Gilbert Mogoko Syed Imam Khalid Rahman Emmanuel Babafemi International Journal of Clinical & Medical Case Reports https://ijcmcr.com/bacillus-cereus-sepsis-in-preterm-neonates-caused-by-central-venous-catheter-a-case-report https://ijcmcr.com/bacillus-cereus-sepsis-in-preterm-neonates-caused-by-central-venous-catheter-a-case-report Fri, 22 Dec 23 00:00:00 +0000 In recent years, Bacillus cereus infection has emerged as a main concern in the field of children's public health. This bacterium, known to be a pollutant, can be found in various settings such as hospital wards, equipment, breast milk, nutrient solution and so on. With its high pathogenicity and toxicity, Bacillus cereus infection can lead to severe and life-threatening symptoms, particularly in premature infants. This case report documents the death of a preterm infant due to Bacillus cereus s... Li Xiaoxiao Long Dianfa Xu Hui Yang Min International Journal of Clinical & Medical Case Reports https://ijcmcr.com/shockwave-intravascular-lithotripsy-facilitated-percutaneous-and-ivus-guided-revascularization-of-left-main-coronary-art https://ijcmcr.com/shockwave-intravascular-lithotripsy-facilitated-percutaneous-and-ivus-guided-revascularization-of-left-main-coronary-art Wed, 22 Nov 23 00:00:00 +0000 Background: Percutaneous coronary intervention (PCI) techniques are evolving, but the management of coronary calcification remains a major challenge for interventional physicians, especially left main coronary artery (LMCA) calcification. Intravascular lithotripsy (IVL) is a relatively new but promising modality for treating calcified lesions, [1] So to date, calcium modification strategies could include any combination of IVL and/or RA with high pressure non-compliant balloon and cutting balloo... Bao Jun Li Baihong Chen Chonghao Gao Changzheng Gu xin Gu Jian bing Wang Xiao-yan International Journal of Clinical & Medical Case Reports https://ijcmcr.com/drug-lnduced-liver-injury-advances-in-antibacterial-antifungal-and-antiviral-drugs https://ijcmcr.com/drug-lnduced-liver-injury-advances-in-antibacterial-antifungal-and-antiviral-drugs Wed, 01 Nov 23 00:00:00 +0000 Drug-induced liver injury (DILI) is an important but rare clinical adverse event and a potential complication of many drugs, which can range from liver enzyme elevations to severe liver failure, liver transplantation even death. The severity of DILI varies from person to person, depending on the type of drug and the state of patients. Most of the drugs commonly prescribed in clinical practice today can be classified as antibacterial, antifungals, and antivirals, which generally summarize the typ... Shi-lu Kang Qian Gao Han-yue Ma Yu-han Zhang Cong Huai Zhi-ling Li International Journal of Clinical & Medical Case Reports https://ijcmcr.com/sacral-fracture-with-neurological-deficit-in-a-young-male-a-case-report-from-afghanistan https://ijcmcr.com/sacral-fracture-with-neurological-deficit-in-a-young-male-a-case-report-from-afghanistan Mon, 21 Aug 23 00:00:00 +0000 Introduction and Importance: Sacral fractures are relatively rare and complex mostly occur due to high-energy trauma. Isolated sacral fractures occur in 5% of cases, and up to 45% of sacral fractures coexist with pelvic ring injuries. Due to the complex and heterogeneous nature of these fractures, diagnosis and treatment of these fractures remain a challenge for the attending surgeon, and treatment is often determined on a case-by-case basis. Case Presentation: In this article, due to unavailabi... Shafi Ullah Zahid International Journal of Clinical & Medical Case Reports https://ijcmcr.com/association-of-dengue-case-load-and-environmental-factors-in-four-potentially-disease-risk-areas-of-pakistan https://ijcmcr.com/association-of-dengue-case-load-and-environmental-factors-in-four-potentially-disease-risk-areas-of-pakistan Mon, 21 Aug 23 00:00:00 +0000 Dengue is a crucial public health dilemma. Scarce water supply, population density, inadequate solid waste management, poor socioeconomic level and climatic variations are recognized as key factors in Aedes breeding and later on in the transmission of Dengue Fever (DF). Dengue incidence (cases) is strongly associated with climatic tiers such as relative humidity, temperature and rainfall. Our findings on values of the bivariate correlation analysis have revealed positive correlation between rain... Hafiza Mufeeza Waseem Akram Rizwan Munir Hafiz Azhar Ali Khan Muhammad Tayyib Hee Il Lee International Journal of Clinical & Medical Case Reports https://ijcmcr.com/exploratory-model-of-climate-and-labor-flexibility https://ijcmcr.com/exploratory-model-of-climate-and-labor-flexibility Wed, 26 Jul 23 00:00:00 +0000 Gross mode, the work climate has been studied as an area inherent in leadership. In the case of the one that is distinguished by its communication and vertical motivation, the work environment has been addressed as a determinant of flexibility in terms of conditions, salaries and benefits. In this regard, the objective of this paper has been to explore the dimensions of climate and labor flexibility in order to establish the dependency relationships between its indicators. A non-experimental, cr... Arturo Sanchez Sanchez Cruz Garcia Lirios Fracisco Espinoza Morales Victor Hugo Meriño Cordoba International Journal of Clinical & Medical Case Reports https://ijcmcr.com/case-of-successful-treatment-of-acute-respiratory-distress-syndrome-in-the-parturient-woman-with-systemic-lupus-erythema https://ijcmcr.com/case-of-successful-treatment-of-acute-respiratory-distress-syndrome-in-the-parturient-woman-with-systemic-lupus-erythema Wed, 26 Jul 23 00:00:00 +0000 Pregnancy and the postpartum period provoke an exacerbation of systemic lupus erythematosus (SLE), which requires aggressive cytostatic therapy that can cause life-threatening conditions for the fetus and complications for the mother, one of which is posterior reversible encephalopathy syndrome (PRES-syndrome). The article describes a clinical case of successful treatment of acute respiratory distress syndrome (ARDS) in a 22-year-old woman in labor with high activity of SLE during pregnancy comp... Kristina Bykova Igor Kasherininov Andrey Bautin Irina Savvina International Journal of Clinical & Medical Case Reports https://ijcmcr.com/trabecular-type-juvenile-ossifying-fibroma-of-mandible https://ijcmcr.com/trabecular-type-juvenile-ossifying-fibroma-of-mandible Wed, 26 Jul 23 00:00:00 +0000 Juvenile ossifying fibroma is a benign lesion with aggressive local growth. It is similar to an ossifying fibroma, although it is more aggressive and of earlier onset. The tumor mainly occurs in juveniles, majority of the patients being 15 years or younger. Radiologically as well as at surgery, the lesion is well demarcated from its surroundings. In this article, we report a case of juvenile ossifying fibroma of mandibular anterior region extending from canine to canine region with expansion of... Shalender Sharma Kaberi Majumder International Journal of Clinical & Medical Case Reports https://ijcmcr.com/functional-and-structural-neurological-and-vascular-lesions-in-long-term-hemodialyzed-patients https://ijcmcr.com/functional-and-structural-neurological-and-vascular-lesions-in-long-term-hemodialyzed-patients Thu, 08 Jun 23 00:00:00 +0000 In patients with short- and -long term hemodialysis treatment several functional and structural neurological and vascular lesions are present that may be dependent on several factors: duration of hemodialysis treatment, age, blood pressure associated with ventricular hypertrophy, extensive vascular calcifications, aritmias. Besides these all patients were evaluated for several clinical data: survival, rehabilitation, nutritional status, anemia, blood pressure, mild-to-moderate ventricular hypert... Claudio Bazzi International Journal of Clinical & Medical Case Reports https://ijcmcr.com/pompe-disease-in-morocco-a-new-mutation-causing-severe-infantile-onset https://ijcmcr.com/pompe-disease-in-morocco-a-new-mutation-causing-severe-infantile-onset Thu, 11 May 23 00:00:00 +0000 Pompe disease is an autosomal recessive disorder caused by a deficiency in 1,4-a-glucosidase, characterized by progressive glycogen accumulation in cellular lysosomes. It ultimately leads to cellular damage. Infantile-onset Pompe disease (IOPD) is the most severe type of this disease and is characterized by severe hypertrophic cardiomyopathy and generalized hypotonia. To date, approximately 400 pathogenic mutations have been reported in the GAA gene. we identified a novel mutation in the acid al... S. Salimi Karima ghema International Journal of Clinical & Medical Case Reports https://ijcmcr.com/leeches-an-unsual-cause-of-epistaxis-in-the-children https://ijcmcr.com/leeches-an-unsual-cause-of-epistaxis-in-the-children Thu, 11 May 23 00:00:00 +0000 Epistaxis is one of the most common ear, nose and throat (ENT) emergencies to present to general practitioners. The leeche is an aquatic worm living in fresh water, especially in tropical areas. It may be found exceptionally in the upper aerodigestive tract (UADT) after consumption of spring water or water from natural wells, after swimming in still waters (lakes and dams), and caused epistaxis, hemoptesis, or laryngeal dyspnea, according to its localisation. We reported a case of 12 year old ch... AL Rajab Sondos Mohamed Ali Gliti Razika Bencheikh Mohamed Anas Benbouzid Abdelilah Oujilal Leila Essakalli Houssyni International Journal of Clinical & Medical Case Reports https://ijcmcr.com/isolated-sphenoidal-aspergillosis-case-report-and-review-of-literature https://ijcmcr.com/isolated-sphenoidal-aspergillosis-case-report-and-review-of-literature Thu, 11 May 23 00:00:00 +0000 Sphenoidal aspergillosis is a rare condition whose diagnosis is not always obvious. The clinician should always bear this diagnosis in mind in patients with chronic sinusitis avoiding invasive and fulminant forms which could be life-threatening. In fact, this work focused on the description of the clinical features of this entity as well as its management by presenting a case report and reviewing literature. Mohamed Ali Gliti Niema Benkhraba Zainab Benyahia Razika Bencheikh Mohamed Anas Benbouzid Abdelilah Oujilal Leila Essakalli Houssyni International Journal of Clinical & Medical Case Reports https://ijcmcr.com/case-report-cerebral-air-embolism-after-transthoracic-needle-lung-biopsy https://ijcmcr.com/case-report-cerebral-air-embolism-after-transthoracic-needle-lung-biopsy Tue, 02 May 23 00:00:00 +0000 Cerebral air embolism is an uncommon, but high morbidity and mortality, event that can be complicated from many medical procedures, including cardiac surgery, venous and arterial access, laparoscopic surgery, or from trauma. Transthoracic needle biopsy is also another diagnostic intervention that can causing this event. Even though risk of air emboli is low, 0.2-0.4%, but its mortality rate is as high as 26%. Clinical presentation can mimic other stroke syndromes but had different mainstay of tr... Chaisak Dumrikarnlert International Journal of Clinical & Medical Case Reports