ijcmcr International Journal of Clinical & Medical Case Reports 2834-250X International Journal of Clinical & Medical Case Reports Review Drug-Lnduced Liver Injury: Advances In Antibacterial, Antifungal And Antiviral Drugs Kang Shi-lu Department of Pharmacy, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China; School of Medicine, Shanghai Jiao Tong University, Shanghai 200125, China Gao Qian Department of Pharmacy, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China; School of Medicine, Shanghai Jiao Tong University, Shanghai 200125, China Ma Han-yue Department of Pharmacy, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China; School of Medicine, Shanghai Jiao Tong University, Shanghai 200125, China Zhang Yu-han Department of Pharmacy, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China; School of Medicine, Shanghai Jiao Tong University, Shanghai 200125, China Huai Cong Bio-X Institutes, Shanghai Jiao Tong University Li Zhi-ling Department of Pharmacy, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China; School of Medicine, Shanghai Jiao Tong University, Shanghai 200125, China 01 11 2023 5 5 10102023 26102023 © 2023 The Author(s). Published by International Journal of Clinical & Medical Case Reports. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC-BY 4.0).

Drug-induced liver injury (DILI) is an important but rare clinical adverse event and a potential complication of many drugs, which can range from liver enzyme elevations to severe liver failure, liver transplantation even death. The severity of DILI varies from person to person, depending on the type of drug and the state of patients. Most of the drugs commonly prescribed in clinical practice today can be classified as antibacterial, antifungals, and antivirals, which generally summarize the types of drugs that cause DILI. Based on the classification of these three drugs, we summarized the literatures of various databases including Pubmed, Embase, JAMA, Web of science, ranging from 1999 to 2020, and the keywords we searched contain drug-induced liver injury, hepatotoxicity, antibiotics, antimicrobial agents antibacterials, antifungals, antivirals, and cholestasis etc., and explained the incidence, main symptoms, duration and other related indicators of DILI with representative drugs of each type. In this review, we summarized and compared the liver injury caused by different anti-infective drugs, which can guide clinicians in the treatment of patients with drug-induced liver injury complicated with infection.

 Antivirals Drug-Induced Liver Injury Antimicrobial Agents Antibacterial Antifungals