Over the world older men are more victim than women for colon cancer and thought third most common type of cancer. Due to the relation with digestive tract with food supply is most important factor with natural diet. Currently, Patients are treated in many numerous ways. Including multidrug resistance, recurrence and lack of treatment for metastases are the main issues in the treatment of colon cancer. Surgery, Chemotherapy, Hormone therapy and radiotherapy are frequently accompanied by adverse effects. Due to their safety, dietary phytochemicals have become effective tools for the treatment and prevention of cancer in recent years. In widely consumed fruits and vegetables Ellagic acid (EA), Sulforaphane (SF), Ursolic acid (UA) have been reported to suppress colon cancer cell proliferation and cause apoptosis. The role of EA, SF and UA in the battle against colon cancer is covered in this review. These agents have been shown to have effects both in vitro and in vivo.